Excess sphingomyelin disturbs ATG9A trafficking and autophagosome closure

Sphingomyelin is an essential cellular lipid that traffics between plasma membrane and intracellular organelles until directed to lysosomes for SMPD1 (sphingomyelin phosphodiesterase 1)-mediated degradation. Inactivating mutations in the SMPD1 gene result in Niemann-Pick diseases type A and B charac...

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Sparad:
Bibliografiska uppgifter
I publikationen:Autophagy
Huvudupphovsmän: Corcelle-Termeau, Elisabeth, Vindeløv, Signe Diness, Hämälistö, Saara, Mograbi, Baharia, Keldsbo, Anne, Bräsen, Jan Hinrich, Favaro, Elena, Adam, Dieter, Szyniarowski, Piotr, Hofman, Paul, Krautwald, Stefan, Farkas, Thomas, Petersen, Nikolaj H.T., Rohde, Mikkel, Linkermann, Andreas, Jäättelä, Marja
Materialtyp: Artigo
Språk:Inglês
Publicerad: Taylor & Francis 2016
Ämnen:
Basic Research Paper
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4854555/
https://ncbi.nlm.nih.gov/pubmed/27070082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2016.1159378
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