Activation of PTHrP-cAMP-CREB1 signaling following p53 loss is essential for osteosarcoma initiation and maintenance

Mutations in the P53 pathway are a hallmark of human cancer. The identification of pathways upon which p53-deficient cells depend could reveal therapeutic targets that may spare normal cells with intact p53. In contrast to P53 point mutations in other cancer, complete loss of P53 is a frequent event...

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Udgivet i:eLife
Main Authors: Walia, Mannu K, Ho, Patricia MW, Taylor, Scott, Ng, Alvin JM, Gupte, Ankita, Chalk, Alistair M, Zannettino, Andrew CW, Martin, T John, Walkley, Carl R
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2016
Fag:
Cell Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4854515/
https://ncbi.nlm.nih.gov/pubmed/27070462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.13446
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