Neural effects of gut‐ and brain‐derived glucagon‐like peptide‐1 and its receptor agonist

Glucagon‐like peptide‐1 (GLP‐1) is derived from both the enteroendocrine L cells and preproglucagon‐expressing neurons in the nucleus tractus solitarius (NTS) of the brain stem. As GLP‐1 is cleaved by dipeptidyl peptidase‐4 yielding a half‐life of less than 2 min, it is plausible that the gut‐derive...

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Bibliografiske detaljer
Udgivet i:J Diabetes Investig
Main Authors: Katsurada, Kenichi, Yada, Toshihiko
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2016
Fag:
Proceedings of INCRETIN 2015, A Symposium Celebrating the 45th Anniversary of the Discovery of GIP, 29–31 July 2015, Vancouver, Canada. This publication has been supported by: The Local Organizing Committee of INCRETIN 2015
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4854507/
https://ncbi.nlm.nih.gov/pubmed/27186358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jdi.12464
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