Novel mutant human immunodeficiency virus type 1 strains with high degree of resistance to cynomolgus macaque TRIMCyp generated by random mutagenesis

Old World monkey TRIM5α strongly suppresses human immunodeficiency virus type 1 (HIV-1) replication. A fusion protein comprising cynomolgus macaque (CM) TRIM5 and cyclophilin A (CM TRIMCyp) also potently suppresses HIV-1 replication. However, CM TRIMCyp fails to suppress a mutant HIV-1 that encodes...

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Bibliografiske detaljer
Udgivet i:J Gen Virol
Main Authors: Sultana, Tahmina, Nakayama, Emi E., Tobita, Satoshi, Yokoyama, Masaru, Seki, Yohei, Saito, Akatsuki, Nomaguchi, Masako, Adachi, Akio, Akari, Hirofumi, Sato, Hironori, Shioda, Tatsuo
Format: Artigo
Sprog:Inglês
Udgivet: Microbiology Society 2016
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4854368/
https://ncbi.nlm.nih.gov/pubmed/26795727
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1099/jgv.0.000408
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