Histone H2AX phosphorylation as a measure of DNA double-strand breaks and a marker of environmental stress and disease activity in lupus

OBJECTIVE: Defective or inefficient DNA double-strand break (DSB) repair results in failure to preserve genomic integrity leading to apoptotic cell death, a hallmark of systemic lupus erythematosus (SLE). Compelling evidence linked environmental factors that increase oxidative stress with SLE risk a...

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Bibliografiska uppgifter
I publikationen:Lupus Sci Med
Huvudupphovsmän: Namas, Rajaie, Renauer, Paul, Ognenovski, Mikhail, Tsou, Pei-Suen, Sawalha, Amr H
Materialtyp: Artigo
Språk:Inglês
Publicerad: BMJ Publishing Group 2016
Ämnen:
Biomarker Studies
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4854117/
https://ncbi.nlm.nih.gov/pubmed/27158526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/lupus-2016-000148
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