Relevance of HCN2-expressing human mesenchymal stem cells for the generation of biological pacemakers

BACKGROUND: The transfection of human mesenchymal stem cells (hMSCs) with the hyperpolarization-activated cyclic nucleotide-gated ion channel 2 (HCN2) gene has been demonstrated to provide biological pacing in dogs with complete heart block. The mechanism appears to be the generation of the ion curr...

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Detalhes bibliográficos
Publicado no:Stem Cell Res Ther
Main Authors: Bruzauskaite, Ieva, Bironaite, Daiva, Bagdonas, Edvardas, Skeberdis, Vytenis Arvydas, Denkovskij, Jaroslav, Tamulevicius, Tomas, Uvarovas, Valentinas, Bernotiene, Eiva
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4853868/
https://ncbi.nlm.nih.gov/pubmed/27137910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13287-016-0326-z
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