Systemic Dosing of Thymosin Beta 4 before and after Ischemia Does Not Attenuate Global Myocardial Ischemia-Reperfusion Injury in Pigs

The use of cardiopulmonary bypass (CPB) and aortic cross-clamping causes myocardial ischemia-reperfusion injury (I-RI) and can lead to reduced postoperative cardiac function. We investigated whether this injury could be attenuated by thymosin beta 4 (TB4), a peptide which has showed cardioprotective...

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Veröffentlicht in:Front Pharmacol
Hauptverfasser: Stark, Christoffer K.-J., Tarkia, Miikka, Kentala, Rasmus, Malmberg, Markus, Vähäsilta, Tommi, Savo, Matti, Hynninen, Ville-Veikko, Helenius, Mikko, Ruohonen, Saku, Jalkanen, Juho, Taimen, Pekka, Alastalo, Tero-Pekka, Saraste, Antti, Knuuti, Juhani, Savunen, Timo, Koskenvuo, Juha
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2016
Schlagworte:
Pharmacology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4853610/
https://ncbi.nlm.nih.gov/pubmed/27199757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2016.00115
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