Common genetic variant association with altered HLA expression, synergy with pyrethroid exposure, and risk for Parkinson’s disease: an observational and case–control study

BACKGROUND: The common noncoding single-nucleotide polymorphism (SNP) rs3129882 in HLA-DRA is associated with risk for idiopathic Parkinson’s disease (PD). The location of the SNP in the major histocompatibility complex class II (MHC-II) locus implicates regulation of antigen presentation as a poten...

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Detalhes bibliográficos
Publicado no:NPJ Parkinsons Dis
Main Authors: Kannarkat, G T, Cook, D A, Lee, J-K, Chang, J, Chung, J, Sandy, E, Paul, K C, Ritz, B, Bronstein, J, Factor, S A, Boss, J M, Tansey, M G
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4853162/
https://ncbi.nlm.nih.gov/pubmed/27148593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npjparkd.2015.2
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