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Synthesis, characterization, and evaluation of mPEG–SN38 and mPEG–PLA–SN38 micelles for cancer therapy
7-Ethyl-10-hydroxy camptothecin (SN38) is a potent topoisomerase inhibitor and a metabolite of irinotecan. Its clinical development has been hampered by its poor solubility. To address this problem, methoxy poly(ethylene glycol)-2000 (mPEG(2K))–SN38 and mPEG(2K)–poly(lactide) (PLA(1.5K))–SN38 conjug...
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| Опубликовано в: : | Int J Nanomedicine |
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| Главные авторы: | , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Dove Medical Press
2016
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4853016/ https://ncbi.nlm.nih.gov/pubmed/27217746 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S103110 |
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