Synthesis, characterization, and evaluation of mPEG–SN38 and mPEG–PLA–SN38 micelles for cancer therapy

7-Ethyl-10-hydroxy camptothecin (SN38) is a potent topoisomerase inhibitor and a metabolite of irinotecan. Its clinical development has been hampered by its poor solubility. To address this problem, methoxy poly(ethylene glycol)-2000 (mPEG(2K))–SN38 and mPEG(2K)–poly(lactide) (PLA(1.5K))–SN38 conjug...

Full description

Saved in:
Bibliographic Details
Published in:Int J Nanomedicine
Main Authors: Xie, Jing, Zhang, Xiaomin, Teng, Meiyu, Yu, Bo, Yang, Shuang, Lee, Robert J, Teng, Lesheng
Format: Artigo
Language:Inglês
Published: Dove Medical Press 2016
Subjects:
Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4853016/
https://ncbi.nlm.nih.gov/pubmed/27217746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S103110
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items