Airway acidification initiates host defense abnormalities in cystic fibrosis mice

Cystic fibrosis (CF) is caused by mutations in the gene that encodes the cystic fibrosis transmembrane conductance regulator (CFTR) anion channel. In humans and pigs, the loss of CFTR impairs respiratory host defenses, causing airway infection. But CF mice are spared. We found that in all three spec...

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Veröffentlicht in:Science
Hauptverfasser: Shah, Viral S., Meyerholz, David K., Tang, Xiao Xiao, Reznikov, Leah, Alaiwa, Mahmoud Abou, Ernst, Sarah E., Karp, Philip H., Wohlford-Lenane, Christine L., Heilmann, Kristopher P., Leidinger, Mariah R., Allen, Patrick D., Zabner, Joseph, McCray, Paul B., Ostedgaard, Lynda S., Stoltz, David A., Randak, Christoph O., Welsh, Michael J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4852973/
https://ncbi.nlm.nih.gov/pubmed/26823428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aad5589
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