Airway acidification initiates host defense abnormalities in cystic fibrosis mice

Cystic fibrosis (CF) is caused by mutations in the gene that encodes the cystic fibrosis transmembrane conductance regulator (CFTR) anion channel. In humans and pigs, the loss of CFTR impairs respiratory host defenses, causing airway infection. But CF mice are spared. We found that in all three spec...

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Detaylı Bibliyografya
Yayımlandı:Science
Asıl Yazarlar: Shah, Viral S., Meyerholz, David K., Tang, Xiao Xiao, Reznikov, Leah, Alaiwa, Mahmoud Abou, Ernst, Sarah E., Karp, Philip H., Wohlford-Lenane, Christine L., Heilmann, Kristopher P., Leidinger, Mariah R., Allen, Patrick D., Zabner, Joseph, McCray, Paul B., Ostedgaard, Lynda S., Stoltz, David A., Randak, Christoph O., Welsh, Michael J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2016
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4852973/
https://ncbi.nlm.nih.gov/pubmed/26823428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aad5589
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