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Autoantigen-specific immunosuppression with tolerogenic peripheral blood cells prevents relapses in a mouse model of relapsing-remitting multiple sclerosis

BACKGROUND: Dendritic cells (DCs) rendered suppressive by treatment with mitomycin C and loaded with the autoantigen myelin basic protein demonstrated earlier their ability to prevent experimental autoimmune encephalomyelitis (EAE), the animal model for multiple sclerosis (MS). This provides an appr...

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Dettagli Bibliografici
Pubblicato in:J Transl Med
Autori principali: Kleist, Christian, Mohr, Elisabeth, Gaikwad, Sadanand, Dittmar, Laura, Kuerten, Stefanie, Platten, Michael, Mier, Walter, Schmitt, Michael, Opelz, Gerhard, Terness, Peter
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2016
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4852098/
https://ncbi.nlm.nih.gov/pubmed/27131971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-016-0860-6
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