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Inhibition of acetyl-CoA carboxylases by soraphen A prevents lipid accumulation and adipocyte differentiation in 3T3-L1 cells

Acetyl-CoA carboxylases (ACC) 1 and 2 catalyze the carboxylation of acetyl-CoA to malonyl-CoA and depend on biotin as a coenzyme. ACC1 localizes in the cytoplasm and produces malonyl-CoA for fatty acid (FA) synthesis. ACC2 localizes in the outer mitochondrial membrane and produces malonyl-CoA that i...

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Detalhes bibliográficos
Publicado no:Eur J Pharmacol
Main Authors: Cordonier, Elizabeth L., Jarecke, Sarah K., Hollinger, Frances E., Zempleni, Janos
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4851891/
https://ncbi.nlm.nih.gov/pubmed/27041646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejphar.2016.03.052
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