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Morphine modulates doxorubicin uptake and improves efficacy of chemotherapy in an intracranial xenograft model of human glioblastoma

Morphine may alter the permeability of Blood-Brain Barrier (BBB), enhancing the access of molecules normally unable to cross it, as Doxorubicin (Dox). In addition, morphine seems to mediate the uptake of Dox into the brain by its reduced efflux mediated by P-glycoprotein (P-gp). We evaluated the ant...

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Podrobná bibliografie
Vydáno v:Am J Cancer Res
Hlavní autoři: da Ros, Martina, Iorio, Anna Lisa, Consolante, Dario, Cardile, Francesco, Muratori, Monica, Fantappiè, Ornella, Lucchesi, Maurizio, Guidi, Milena, Pisano, Claudio, Sardi, Iacopo
Médium: Artigo
Jazyk:Inglês
Vydáno: e-Century Publishing Corporation 2016
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4851843/
https://ncbi.nlm.nih.gov/pubmed/27152241
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