Combined Treatment with Doxorubicin and Rapamycin Is Effective against In Vitro and In Vivo Models of Human Glioblastoma

Despite numerous clinical trials, glioblastoma (GBM) remains a tumor that is difficult to treat. The aim of this study was to investigate the potential of a new pharmacological approach, combining doxorubicin (Dox) and rapamycin (Rapa), in in vitro and in vivo GBM models. Cytotoxic and anti-prolifer...

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Detalhes bibliográficos
Main Authors: Anna Lisa Iorio, Martina Da Ros, Claudio Pisano, Maurizio de Martino, Lorenzo Genitori, Iacopo Sardi
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2019-03-01
Colecção:Journal of Clinical Medicine
Assuntos:
doxorubicin
rapamycin
glioblastoma
mTOR inhibitor
chemotherapy
Acesso em linha:http://www.mdpi.com/2077-0383/8/3/331
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