Neuron-immune mechanisms contribute to pain in early stages of arthritis

BACKGROUND: Rheumatoid arthritis (RA) patients frequently show weak correlations between the magnitude of pain and inflammation suggesting that mechanisms other than overt peripheral inflammation contribute to pain in RA. We assessed changes in microglial reactivity and spinal excitability and their...

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Udgivet i:J Neuroinflammation
Main Authors: Nieto, Francisco R., Clark, Anna K., Grist, John, Hathway, Gareth J., Chapman, Victoria, Malcangio, Marzia
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2016
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4851814/
https://ncbi.nlm.nih.gov/pubmed/27130316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-016-0556-0
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