Alternatively activated macrophages boost iTreg and Th17 cell responses during immunotherapy for colitis

Induced regulatory T (iTreg) and T helper 17 (Th17) cells promote mucosal homeostasis. We used a T cell transfer model of colitis to compare the capacity of iTreg and Th17 cells to develop in situ following the transfer of naïve CD4(+) CD45RB(hi) T cells into Rag1(−/−) C57BL/6 or BALB/c mice, the pr...

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Veröffentlicht in:J Immunol
Hauptverfasser: Haribhai, Dipica, Ziegelbauer, Jennifer, Jia, Shuang, Upchurch, Kyle, Yan, Ke, Schmitt, Erica G., Salzman, Nita H., Simpson, Pippa, Hessner, Martin J., Chatila, Talal A., Williams, Calvin B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4851766/
https://ncbi.nlm.nih.gov/pubmed/26927797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1501956
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