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RNF8 deficiency results in neurodegeneration in mice

The progressive loss of neurons causes neurodegenerative diseases. Because the accumulation of DNA breaks results in neuronal apoptosis, the lack of a variety of DNA damage repair-related proteins contributes to neurodegeneration. The ubiquitin ligase RNF8 plays an important role in DNA double-stran...

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Foilsithe in:Neurobiol Aging
Main Authors: Ouyang, Siwei, Song, Yanfeng, Tian, Yingxia, Chen, Yibin, Yu, Xiaochun, Wang, Degui
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2015
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4851709/
https://ncbi.nlm.nih.gov/pubmed/26256786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2015.07.010
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