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WNT-SHH Antagonism Specifies and Expands Stem Cells Prior to Niche Formation
Adult stem cell (SC) maintenance and differentiation are known to depend on signals received from the niche. Here however, we demonstrate a mechanism for SC specification and regulation that is niche-independent. Using immunofluorescence, live imaging, genetics, cell-cycle analyses, in utero lentivi...
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| Publicado no: | Cell |
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| Principais autores: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4850916/ https://ncbi.nlm.nih.gov/pubmed/26771489 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2015.11.058 |
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