Sildenafil, a cyclic GMP phosphodiesterase inhibitor, induces microglial modulation after focal ischemia in the neonatal mouse brain

BACKGROUND: Perinatal ischemic stroke is the most frequent form of cerebral infarction in neonates; however, evidence-based treatments are currently lacking. We have previously demonstrated a beneficial effect of sildenafil citrate, a PDE-5 inhibitor, on stroke lesion size in neonatal rat pups. The...

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Bibliografiske detaljer
Udgivet i:J Neuroinflammation
Main Authors: Moretti, Raffaella, Leger, Pierre-Louis, Besson, Valérie C., Csaba, Zsolt, Pansiot, Julien, Di Criscio, Lorena, Gentili, Andrea, Titomanlio, Luigi, Bonnin, Philippe, Baud, Olivier, Charriaut-Marlangue, Christiane
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2016
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4850658/
https://ncbi.nlm.nih.gov/pubmed/27126393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-016-0560-4
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