Phenylbutazone induces expression of MBNL1 and suppresses formation of MBNL1-CUG RNA foci in a mouse model of myotonic dystrophy

Myotonic dystrophy type 1 (DM1) is caused by abnormal expansion of CTG repeats in the 3′ untranslated region of the DMPK gene. Expanded CTG repeats are transcribed into RNA and make an aggregate with a splicing regulator, MBNL1, in the nucleus, which is called the nuclear foci. The nuclear foci sequ...

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:Sci Rep
Autors principals: Chen, Guiying, Masuda, Akio, Konishi, Hiroyuki, Ohkawara, Bisei, Ito, Mikako, Kinoshita, Masanobu, Kiyama, Hiroshi, Matsuura, Tohru, Ohno, Kinji
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2016
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4850456/
https://ncbi.nlm.nih.gov/pubmed/27126921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep25317
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars