Inhibition of cyclooxygenase-1 by nonsteroidal anti-inflammatory drugs demethylates MeR2 enhancer and promotes Mbnl1 transcription in myogenic cells

Muscleblind-like 1 (MBNL1) is a ubiquitously expressed RNA-binding protein, which is highly expressed in skeletal muscle. Abnormally expanded CUG-repeats in the DMPK gene cause myotonic dystrophy type 1 (DM1) by sequestration of MBNL1 to nuclear RNA foci and by upregulation of another RNA-binding pr...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Huang, Kun, Masuda, Akio, Chen, Guiying, Bushra, Samira, Kamon, Masayoshi, Araki, Toshiyuki, Kinoshita, Masanobu, Ohkawara, Bisei, Ito, Mikako, Ohno, Kinji
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7018979/
https://ncbi.nlm.nih.gov/pubmed/32054946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-59517-y
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