RNF8 E3 Ubiquitin Ligase Stimulates Ubc13 E2 Conjugating Activity That Is Essential for DNA Double Strand Break Signaling and BRCA1 Tumor Suppressor Recruitment

DNA double strand break (DSB) responses depend on the sequential actions of the E3 ubiquitin ligases RNF8 and RNF168 plus E2 ubiquitin-conjugating enzyme Ubc13 to specifically generate histone Lys-63-linked ubiquitin chains in DSB signaling. Here, we defined the activated RNF8-Ubc13∼ubiquitin comple...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Hodge, Curtis D., Ismail, Ismail H., Edwards, Ross A., Hura, Greg L., Xiao, Andrew T., Tainer, John A., Hendzel, Michael J., Glover, J. N. Mark
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4850281/
https://ncbi.nlm.nih.gov/pubmed/26903517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.715698
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