Sterile inflammation induced by Carbopol elicits robust adaptive immune responses in the absence of pathogen-associated molecular patterns

Carbopol is a polyanionic carbomer used in man for topical application and drug delivery purposes. However parenteral administration of Carbopol in animal models results in systemic adjuvant activity including strong pro-inflammatory type-1 T-cell (Th1) polarization. Here we investigated potential p...

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Publicado en:Vaccine
Autores principales: Gartlan, Kate H., Krashias, George, Wegmann, Frank, Hillson, William R., Scherer, Erin M., Greenberg, Philip D., Eisenbarth, Stephanie C., Moghaddam, Amin E., Sattentau, Quentin J.
Formato: Artigo
Lenguaje:Inglês
Publicado: Elsevier Science 2016
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4850248/
https://ncbi.nlm.nih.gov/pubmed/27005810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2016.03.025
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