Complement Factor H-Related 5-Hybrid Proteins Anchor Properdin and Activate Complement at Self-Surfaces

C3 glomerulopathy (C3G) is a severe kidney disease for which no specific therapy exists. The causes of C3G are heterogeneous, and defective complement regulation is often linked to C3G pathogenesis. Copy number variations in the complement factor H-related (CFHR) gene cluster on chromosome 1q32 and...

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Detalhes bibliográficos
Publicado no:J Am Soc Nephrol
Main Authors: Chen, Qian, Manzke, Melanie, Hartmann, Andrea, Büttner, Maike, Amann, Kerstin, Pauly, Diana, Wiesener, Michael, Skerka, Christine, Zipfel, Peter F.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Nephrology 2016
Assuntos:
Basic Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4849819/
https://ncbi.nlm.nih.gov/pubmed/26432903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2015020212
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