IL-5 links adaptive and natural immunity specific for epitopes of oxidized LDL and protects from atherosclerosis

During atherogenesis, LDL is oxidized, generating various oxidation-specific neoepitopes, such as malondialdehyde-modified (MDA-modified) LDL (MDA-LDL) or the phosphorylcholine (PC) headgroup of oxidized phospholipids (OxPLs). These epitopes are recognized by both adaptive T cell–dependent (TD) and...

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Autori principali: Binder, Christoph J., Hartvigsen, Karsten, Chang, Mi-Kyung, Miller, Marina, Broide, David, Palinski, Wulf, Curtiss, Linda K., Corr, Maripat, Witztum, Joseph L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2004
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC484976/
https://ncbi.nlm.nih.gov/pubmed/15286809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200420479
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