The interchange of immunophilins leads to parallel pathways and different intermediates in the assembly of Hsp90 glucocorticoid receptor complexes

Hormone receptors require participation of the chaperones Hsp40/Hsp70 to form client-transfer complexes with Hsp90/Hop. Interaction with the co-chaperone p23 releases Hop and Hsp70, and the immunophilin FKBP52 mediates transfer of the Hsp90-receptor complex to the nucleus. Inhibition of glucocortico...

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Publicado en:Cell Discov
Autores principales: Ebong, Ima-obong, Beilsten-Edmands, Victoria, Patel, Nisha A, Morgner, Nina, Robinson, Carol V
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2016
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4849472/
https://ncbi.nlm.nih.gov/pubmed/27462449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/celldisc.2016.2
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