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Smad3 Sensitizes Hepatocelluar Carcinoma Cells to Cisplatin by Repressing Phosphorylation of AKT

Background: Heptocelluar carcinoma (HCC) is insensitive to chemotherapy due to limited bioavailability and acquired drug resistance. Smad3 plays dual roles by inhibiting cell growth initially and promoting the progression of advanced tumors in HCC. However, the role of smad3 in chemosensitivity of H...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Zhou, Hong-Hao, Chen, Lin, Liang, Hui-Fang, Li, Guang-Zhen, Zhang, Bi-Xiang, Chen, Xiao-Ping
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4849060/
https://ncbi.nlm.nih.gov/pubmed/27110775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms17040610
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