A PARP1-ERK2 synergism is required for the induction of LTP

Unexpectedly, a post-translational modification of DNA-binding proteins, initiating the cell response to single-strand DNA damage, was also required for long-term memory acquisition in a variety of learning paradigms. Our findings disclose a molecular mechanism based on PARP1-Erk synergism, which ma...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Visochek, L., Grigoryan, G., Kalal, A., Milshtein-Parush, H., Gazit, N., Slutsky, I., Yeheskel, A., Shainberg, A., Castiel, A., Seger, R., Langelier, M. F., Dantzer, F., Pascal, J. M., Segal, M., Cohen-Armon, M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4848477/
https://ncbi.nlm.nih.gov/pubmed/27121568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep24950
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