Morphine-induced antinociception and reward in “humanized” mice expressing the mu opioid receptor A118G polymorphism

The rewarding and antinociceptive effects of opioids are mediated through the mu-opioid receptor. The A118G single nucleotide polymorphism in this receptor has been implicated in drug addiction and differences in pain response. Clinical and preclinical studies have found that the G allele is associa...

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Bibliographic Details
Published in:Brain Res Bull
Main Authors: Henderson-Redmond, Angela N, Yuill, Matthew B, Lowe, Tammy E, Kline, Aaron M, Zee, Michael L, Guindon, Josée, Morgan, Daniel J
Format: Artigo
Language:Inglês
Published: 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4848164/
https://ncbi.nlm.nih.gov/pubmed/26521067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.brainresbull.2015.10.007
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