Development of Th17-associated interstitial kidney inflammation in lupus-prone mice lacking the gene encoding Signal Transduction and Activator of Transcription-1 (STAT-1)

Type I interferon (IFN-I) signaling is a central pathogenic pathway in Systemic Lupus Erythematosus (SLE), and therapeutics targeting IFN-I signaling are in development. Multiple proteins with overlapping function participate in IFN signaling, but the signaling events downstream of receptor engageme...

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Veröffentlicht in:Arthritis Rheumatol
Hauptverfasser: Yiu, Gloria, Rasmussen, Tue Kruse, Ajami, Bahareh, Haddon, David J., Chu, Alvina D., Tangsombatvisit, Stephanie, Haynes, Winston A., Diep, Vivian, Steinman, Larry, Faix, James, Utz, Paul J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4848130/
https://ncbi.nlm.nih.gov/pubmed/26636548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.39535
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