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Francisella tularensis Modulates a Distinct Subset of Regulatory Factors and Sustains Mitochondrial Integrity to Impair Human Neutrophil Apoptosis

Tularemia is a disease characterized by profound neutrophil accumulation and tissue destruction. The causative organism, Francisella tularensis, is a facultative intracellular bacterium that replicates in neutrophil cytosol, inhibits caspase activation and profoundly prolongs cell lifespan. Here, we...

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Pubblicato in:J Innate Immun
Autori principali: McCracken, Jenna M., Kinkead, Lauren C., McCaffrey, Ramona L., Allen, Lee-Ann H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: S. Karger AG 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4848127/
https://ncbi.nlm.nih.gov/pubmed/26906922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000443882
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