A bacteriophage endolysin that eliminates intracellular streptococci

PlyC, a bacteriophage-encoded endolysin, lyses Streptococcus pyogenes (Spy) on contact. Here, we demonstrate that PlyC is a potent agent for controlling intracellular Spy that often underlies refractory infections. We show that the PlyC holoenzyme, mediated by its PlyCB subunit, crosses epithelial c...

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Detalles Bibliográficos
Publicado en:eLife
Main Authors: Shen, Yang, Barros, Marilia, Vennemann, Tarek, Gallagher, D Travis, Yin, Yizhou, Linden, Sara B, Heselpoth, Ryan D, Spencer, Dennis J, Donovan, David M, Moult, John, Fischetti, Vincent A, Heinrich, Frank, Lösche, Mathias, Nelson, Daniel C
Formato: Artigo
Idioma:Inglês
Publicado: eLife Sciences Publications, Ltd 2016
Assuntos:
Biochemistry
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4848087/
https://ncbi.nlm.nih.gov/pubmed/26978792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.13152
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