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Potential C-terminal-domain inhibitors of heat shock protein 90 derived from a C-terminal peptide helix

Hsp90 is a molecular chaperone implicated in many diseases including cancer and neurodegenerative disease. Most inhibitors target the ATPase site in Hsp90’s N-terminal domain, with relatively few inhibitors of other domains reported to date. Here, we show that peptides derived from a short helix at...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Bioorg Med Chem
Main Authors: Gavenonis, Jason, Jonas, Nicholas E., Kritzer, Joshua A.
Format: Artigo
Jezik:Inglês
Izdano: 2014
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4847944/
https://ncbi.nlm.nih.gov/pubmed/24984936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2014.06.006
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