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Activation of spinal MrgC-Gi-NR2B-nNOS signaling pathway by Mas oncogene-related gene C receptor agonist bovine adrenal medulla 8-22 attenuates bone cancer pain in mice

Objectives: In the present study, we investigate the effects of Mas oncogene-related gene (Mrg) C receptors (MrgC) on the expression and activation of spinal Gi protein, N-methyl-D-aspartate receptor subunit 2B (NR2B), and neuronal nitric oxide synthase (nNOS) in mouse model of bone cancer pain. Met...

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Detalhes bibliográficos
Publicado no:Am J Transl Res
Main Authors: Sun, Yu’e, Zhang, Juan, Lei, Yishan, Lu, Cui’e, Hou, Bailing, Ma, Zhengliang, Gu, Xiaoping
Formato: Artigo
Idioma:Inglês
Publicado em: e-Century Publishing Corporation 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4846957/
https://ncbi.nlm.nih.gov/pubmed/27158400
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