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Adeno-associated virus mediated SOD gene therapy protects the retinal ganglion cells from chronic intraocular pressure elevation induced injury via attenuating oxidative stress and improving mitochondrial dysfunction in a rat model
Purpose: This study aimed to determine whether chronic intraocular pressure (IOP) elevation induces retinal oxidative stress and alters mitochondrial morphology and function of retinal ganglion cells (RGC) and to explore the effects of AAV-SOD2 gene therapy on the RGC survival and mitochondrial dysf...
保存先:
出版年: | Am J Transl Res |
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主要な著者: | , , , |
フォーマット: | Artigo |
言語: | Inglês |
出版事項: |
e-Century Publishing Corporation
2016
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主題: | |
オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4846927/ https://ncbi.nlm.nih.gov/pubmed/27158370 |
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