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Adeno-associated virus mediated SOD gene therapy protects the retinal ganglion cells from chronic intraocular pressure elevation induced injury via attenuating oxidative stress and improving mitochondrial dysfunction in a rat model

Purpose: This study aimed to determine whether chronic intraocular pressure (IOP) elevation induces retinal oxidative stress and alters mitochondrial morphology and function of retinal ganglion cells (RGC) and to explore the effects of AAV-SOD2 gene therapy on the RGC survival and mitochondrial dysf...

詳細記述

保存先:
書誌詳細
出版年:Am J Transl Res
主要な著者: Jiang, Wenmin, Tang, Luosheng, Zeng, Jun, Chen, Baihua
フォーマット: Artigo
言語:Inglês
出版事項: e-Century Publishing Corporation 2016
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4846927/
https://ncbi.nlm.nih.gov/pubmed/27158370
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