Transcriptome signature for dampened Th2 dominance in acellular pertussis vaccine-induced CD4(+) T cell responses through TLR4 ligation

Current acellular pertussis (aP) vaccines promote a T helper 2 (Th2)-dominated response, while Th1/Th17 cells are protective. As our previous study showed, after adding a non-toxic TLR4 ligand, LpxL1, to the aP vaccine in mice, the Bordetella pertussis-specific Th2 response is decreased and Th1/Th17...

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Bibliografische gegevens
Gepubliceerd in:Sci Rep
Hoofdauteurs: Brummelman, Jolanda, Raeven, René H. M., Helm, Kina, Pennings, Jeroen L. A., Metz, Bernard, van Eden, Willem, van Els, Cécile A. C. M., Han, Wanda G. H.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group 2016
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4846868/
https://ncbi.nlm.nih.gov/pubmed/27118638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep25064
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