Harmine suppresses homologous recombination repair and inhibits proliferation of hepatoma cells

To avoid cell cycle arrest or apoptosis, rapidly proliferating cancer cells have to promote DNA double strand break (DSB) repair to fix replication stress induced DSBs. Therefore, developing drugs blocking homologous recombination (HR) and nonhomologous end joining (NHEJ) – 2 major DSB repair pathwa...

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Bibliografski detalji
Izdano u:Cancer Biol Ther
Glavni autori: Zhang, Lei, Zhang, Fan, Zhang, Wenjun, Chen, Lu, Gao, Neng, Men, Yulong, Xu, Xiaojun, Jiang, Ying
Format: Artigo
Jezik:Inglês
Izdano: Taylor & Francis 2015
Teme:
Research Papers
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4846143/
https://ncbi.nlm.nih.gov/pubmed/26382920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384047.2015.1078021
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