Harmine suppresses homologous recombination repair and inhibits proliferation of hepatoma cells

To avoid cell cycle arrest or apoptosis, rapidly proliferating cancer cells have to promote DNA double strand break (DSB) repair to fix replication stress induced DSBs. Therefore, developing drugs blocking homologous recombination (HR) and nonhomologous end joining (NHEJ) – 2 major DSB repair pathwa...

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Dettagli Bibliografici
Pubblicato in:Cancer Biol Ther
Autori principali: Zhang, Lei, Zhang, Fan, Zhang, Wenjun, Chen, Lu, Gao, Neng, Men, Yulong, Xu, Xiaojun, Jiang, Ying
Natura: Artigo
Lingua:Inglês
Pubblicazione: Taylor & Francis 2015
Soggetti:
Research Papers
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4846143/
https://ncbi.nlm.nih.gov/pubmed/26382920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384047.2015.1078021
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