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The important tumor suppressor role of PER1 in regulating the cyclin–CDK–CKI network in SCC15 human oral squamous cell carcinoma cells

BACKGROUND: Accumulating evidence suggests that the abnormal expression of the circadian clock gene PER1 is closely related to the development and progression of cancer. However, the exact molecular mechanism by which the abnormal expression of PER1 induces carcinogenesis is unclear. This study was...

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Publicat a:Onco Targets Ther
Autors principals: Fu, Xiao-Juan, Li, Han-Xue, Yang, Kai, Chen, Dan, Tang, Hong
Format: Artigo
Idioma:Inglês
Publicat: Dove Medical Press 2016
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4846057/
https://ncbi.nlm.nih.gov/pubmed/27143919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/OTT.S100952
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