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Differential requirement for IL-2 and IL-15 during bifurcated development of thymic regulatory T cells

The developmental pathways of regulatory T cells (T(reg)) generation in the thymus are not fully understood. Here, we reconstituted thymic development of Zap70 deficient thymocytes with a tetracycline inducible Zap70 transgene to allow temporal dissection of T(reg) development. We find that T(reg) d...

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Detalhes bibliográficos
Publicado no:J Immunol
Main Authors: Marshall, Daniel, Sinclair, Charles, Tung, Sim, Seddon, Benedict
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4845883/
https://ncbi.nlm.nih.gov/pubmed/25348623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1402144
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