Analysis of RET promoter CpG island methylation using methylation-specific PCR (MSP), pyrosequencing, and methylation-sensitive high-resolution melting (MS-HRM): impact on stage II colon cancer patient outcome

BACKGROUND: Already since the 1990s, promoter CpG island methylation markers have been considered promising diagnostic, prognostic, and predictive cancer biomarkers. However, so far, only a limited number of DNA methylation markers have been introduced into clinical practice. One reason why the vast...

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Veröffentlicht in:Clin Epigenetics
Hauptverfasser: Draht, Muriel X. G., Smits, Kim M., Jooste, Valérie, Tournier, Benjamin, Vervoort, Martijn, Ramaekers, Chantal, Chapusot, Caroline, Weijenberg, Matty P., van Engeland, Manon, Melotte, Veerle
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2016
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Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4845472/
https://ncbi.nlm.nih.gov/pubmed/27118999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13148-016-0211-8
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