The heme–p53 interaction: Linking iron metabolism to p53 signaling and tumorigenesis

Recently, we reported that heme binds to tumor suppressor p53 protein (TP53, best known as p53) and promotes its nuclear export and cytosolic degradation, whereas iron chelation stabilizes p53 protein and suppresses tumors in a p53-dependent manner. This not only provides mechanistic insights into t...

Ful tanımlama

Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Mol Cell Oncol
Asıl Yazarlar: Shen, Jia, Sheng, Xiangpeng, Chang, ZeNan, Wu, Qian, Xie, Dong, Wang, Fudi, Hu, Ronggui
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Taylor & Francis 2014
Konular:
Commentary
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4845248/
https://ncbi.nlm.nih.gov/pubmed/27308524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/23723548.2014.965642
Etiketler: Etiketle
Etiket eklenmemiş, İlk siz ekleyin!

Benzer Materyaller