The heme–p53 interaction: Linking iron metabolism to p53 signaling and tumorigenesis

Recently, we reported that heme binds to tumor suppressor p53 protein (TP53, best known as p53) and promotes its nuclear export and cytosolic degradation, whereas iron chelation stabilizes p53 protein and suppresses tumors in a p53-dependent manner. This not only provides mechanistic insights into t...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Mol Cell Oncol
Egile Nagusiak: Shen, Jia, Sheng, Xiangpeng, Chang, ZeNan, Wu, Qian, Xie, Dong, Wang, Fudi, Hu, Ronggui
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Taylor & Francis 2014
Gaiak:
Commentary
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4845248/
https://ncbi.nlm.nih.gov/pubmed/27308524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/23723548.2014.965642
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