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When the guardian becomes the enemy: Targeting ATM in PTEN-deficient cancers
Ataxia telangiectasia mutated (ATM) is an important signaling molecule in the DNA damage response and inhibitors of ATM are under clinical development. We identified a synthetic lethal interaction between ATM inhibition and phosphatase and tensin homolog (PTEN) loss that was the result of increased...
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| Veröffentlicht in: | Mol Cell Oncol |
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| Hauptverfasser: | , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Taylor & Francis
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4845205/ https://ncbi.nlm.nih.gov/pubmed/27308567 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/23723556.2015.1053595 |
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