LY395756, an mGluR2 agonist and mGluR3 antagonist, enhances NMDA receptor expression and function in the normal adult rat prefrontal cortex, but fails to improve working memory and reverse MK801-induced working memory impairment

Targeting group II metabotropic glutamate receptors (mGluR2/3) has been proposed to correct the dysfunctional glutamatergic system, particularly NMDA receptor (NMDAR) hypofunction, for treatment of schizophrenia. However, how activation of mGluR2/3 affects NMDAR function in adult animals remains elu...

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Detalhes bibliográficos
Publicado no:Exp Neurol
Main Authors: Li, Meng-Lin, Yang, Sha-Sha, Xing, Bo, Ferguson, Brielle R., Gulchina, Yelena, Li, Yan-Chun, Li, Feng, Hu, Xi-Quan, Gao, Wen-Jun
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4845095/
https://ncbi.nlm.nih.gov/pubmed/26341392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.expneurol.2015.08.019
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