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IL-13 mediates collagen deposition via STAT6 and microRNA-135b: a role for epigenetics

Systemic sclerosis is an autoimmune connective tissue disease in which T cells play a prominent role. We and others have previously demonstrated a role for T cell-derived IL-13 in mediating the induction of collagen in dermal fibroblasts and that blockade with IL-13 antibodies attenuates this increa...

詳細記述

保存先:
書誌詳細
出版年:Sci Rep
主要な著者: O’Reilly, Steven, Ciechomska, Marzena, Fullard, Nicola, Przyborski, Stefan, van Laar, Jacob M.
フォーマット: Artigo
言語:Inglês
出版事項: Nature Publishing Group 2016
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4844987/
https://ncbi.nlm.nih.gov/pubmed/27113293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep25066
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