A novel, orally-bioavailable nociceptin receptor antagonist, LY2940094, reduces ethanol self-administration and ethanol-seeking in animal models

BACKGROUND: The nociceptin/orphanin-FQ (NOP; or opioid-receptor-like (ORL1)) receptor is localized in the mesolimbic reward pathway and has been suggested to play a role in feeding, mood, stress, and addiction. Since its deorphanization in 1995, there has been a clear dichotomy in the literature reg...

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Publié dans:Alcohol Clin Exp Res
Auteurs principaux: Rorick-Kehn, Linda M., Ciccocioppo, Roberto, Wong, Conrad J., Witkin, Jeffrey M., Martínez-Grau, Maria A., Stopponi, Serena, Adams, Benjamin L., Katner, Jason S., Perry, Kenneth W., Toledo, Miguel A., Diaz, Nuria, Lafuente, Celia, Jiménez, Alma, Benito, Ana, Pedregal, Concepcion, Weiss, Friedbert, Statnick, Michael A.
Format: Artigo
Langue:Inglês
Publié: 2016
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4844902/
https://ncbi.nlm.nih.gov/pubmed/27084498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acer.13052
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