Peroxiredoxin 6 homodimerization and heterodimerization with glutathione S-transferase pi are required for its peroxidase but not phospholipase A(2) activity

Peroxiredoxin 6 (Prdx6) is a unique 1-Cys member of the peroxiredoxin family with both GSH peroxidase and phospholipase A(2) (PLA(2)) activities. It is highly expressed in the lung where it plays an important role in antioxidant defense and lung surfactant metabolism. Glutathionylation of Prdx6 medi...

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Publicat a:Free Radic Biol Med
Autors principals: Zhou, Suiping, Sorokina, Elena M., Harper, Sandra, Li, Haitao, Ralat, Luis, Dodia, Chandra, Speicher, David W., Feinstein, Sheldon I., Fisher, Aron B.
Format: Artigo
Idioma:Inglês
Publicat: 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4844822/
https://ncbi.nlm.nih.gov/pubmed/26891882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2016.02.012
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