Rifampin phosphotransferase is an unusual antibiotic resistance kinase

Rifampin (RIF) phosphotransferase (RPH) confers antibiotic resistance by conversion of RIF and ATP, to inactive phospho-RIF, AMP and P(i). Here we present the crystal structure of RPH from Listeria monocytogenes (RPH-Lm), which reveals that the enzyme is comprised of three domains: two substrate-bin...

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Gepubliceerd in:Nat Commun
Hoofdauteurs: Stogios, Peter J., Cox, Georgina, Spanogiannopoulos, Peter, Pillon, Monica C., Waglechner, Nicholas, Skarina, Tatiana, Koteva, Kalinka, Guarné, Alba, Savchenko, Alexei, Wright, Gerard D.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group 2016
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4844700/
https://ncbi.nlm.nih.gov/pubmed/27103605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms11343
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