The molecular basis of the genesis of basal tone in internal anal sphincter

Smooth muscle sphincters exhibit basal tone and control passage of contents through organs such as the gastrointestinal tract; loss of this tone leads to disorders such as faecal incontinence. However, the molecular mechanisms underlying this tone remain unknown. Here, we show that deletion of myosi...

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Publicado no:Nat Commun
Main Authors: Zhang, Cheng-Hai, Wang, Pei, Liu, Dong-Hai, Chen, Cai-Ping, Zhao, Wei, Chen, Xin, Chen, Chen, He, Wei-Qi, Qiao, Yan-Ning, Tao, Tao, Sun, Jie, Peng, Ya-Jing, Lu, Ping, Zheng, Kaizhi, Craige, Siobhan M., Lifshitz, Lawrence M., Keaney Jr, John F., Fogarty, Kevin E., ZhuGe, Ronghua, Zhu, Min-Sheng
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4844698/
https://ncbi.nlm.nih.gov/pubmed/27101932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms11358
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