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The molecular basis of the genesis of basal tone in internal anal sphincter

Smooth muscle sphincters exhibit basal tone and control passage of contents through organs such as the gastrointestinal tract; loss of this tone leads to disorders such as faecal incontinence. However, the molecular mechanisms underlying this tone remain unknown. Here, we show that deletion of myosi...

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Bibliografiske detaljer
Udgivet i:Nat Commun
Main Authors: Zhang, Cheng-Hai, Wang, Pei, Liu, Dong-Hai, Chen, Cai-Ping, Zhao, Wei, Chen, Xin, Chen, Chen, He, Wei-Qi, Qiao, Yan-Ning, Tao, Tao, Sun, Jie, Peng, Ya-Jing, Lu, Ping, Zheng, Kaizhi, Craige, Siobhan M., Lifshitz, Lawrence M., Keaney Jr, John F., Fogarty, Kevin E., ZhuGe, Ronghua, Zhu, Min-Sheng
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4844698/
https://ncbi.nlm.nih.gov/pubmed/27101932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms11358
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