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Site-specific Proteasome Phosphorylation Controls Cell Proliferation and Tumorigenesis

Despite the fundamental importance of proteasomal degradation in cells, little is known about whether and how the 26S proteasome itself is regulated in coordination with various physiological processes. Here we show that the proteasome is dynamically phosphorylated during cell cycle at Thr25 of the...

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Detalhes bibliográficos
Publicado no:Nat Cell Biol
Main Authors: Guo, Xing, Wang, Xiaorong, Wang, Zhiping, Banerjee, Sourav, Yang, Jing, Huang, Lan, Dixon, Jack E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4844191/
https://ncbi.nlm.nih.gov/pubmed/26655835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb3289
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